Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651742 | 0.88 | HSD17B10 (0.52) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7649974 | 0.86 | MAPK10 (0.55) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7651129 | 0.83 | CA12 (0.51) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7649673 | 0.83 | HSD17B10 (0.67) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7648336 | 0.83 | HSD17B10 (0.67) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7654811 | 0.81 | HSD17B10 (0.71) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8191504 | 0.80 | FAAH (0.51) | ALDH1A1LMNAFAAH | |
| SCHEMBL7655539 | 0.80 | LMNA (0.47) | HSD17B10MAPK10SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8191452 | 0.77 | GRIK1 (0.48) | ALDH1A1LMNAFAAHGAA | |
| SCHEMBL30661068 | 0.77 | GRIK1 (0.48) | ALDH1A1LMNAFAAHGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |