Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650167 | 0.90 | ROCK2 (0.45) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7652124 | 0.89 | MAPT (0.52) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7655163 | 0.82 | MAPT (0.46) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7656595 | 0.78 | ROCK2 (0.39) | KCNQ3KCNQ2ROCK2 | |
| SCHEMBL7659693 | 0.77 | MEN1 (0.44) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL6299417 | 0.77 | ROCK2 (0.59) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7655629 | 0.76 | ROCK2 (0.50) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7649761 | 0.76 | MAPT (0.46) | KMT2AMEN1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7659674 | 0.73 | MAPT (0.60) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL6295125 | 0.73 | ABCB1 (0.52) | MAPTSMN1; SMN2ALOX15ALOX12NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | claimed |
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |