Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668380 | 0.86 | HPGD (0.70) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL12514085 | 0.82 | HDAC3 (0.59) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL2693481 | 0.79 | LMNA (0.77) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL335624 | 0.79 | DAO (0.64) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL3055322 | 0.78 | YEATS4 (0.54) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL12321245 | 0.78 | YEATS4 (0.54) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL10293769 | 0.78 | YEATS4 (0.54) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL12737782 | 0.76 | YEATS4 (0.53) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL19059411 | 0.74 | YEATS4 (0.51) | TSHRMAPK1NPSR1HPGDL3MBTL1 | |
| SCHEMBL10649689 | 0.74 | YEATS4 (0.51) | TSHRMAPK1NPSR1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6491903-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY | WASHINGTON UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-6383500-B1 | Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications | WASHINGTON UNIVERSITY | 2002-05-07 | — | — | US | disclosed |