Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657987 | 0.85 | CA1 (0.39) | CSF1RRAB9ACA1CA2CA7 | |
| SCHEMBL7650161 | 0.84 | CA1 (0.35) | NPC1POLBRAB9ACA1CA2 | |
| SCHEMBL7104666 | 0.82 | — | — | |
| SCHEMBL7655274 | 0.77 | NPC1 (0.34) | NPC1POLBRAB9A | |
| SCHEMBL7105229 | 0.73 | — | — | |
| SCHEMBL7650762 | 0.72 | NPC1 (0.33) | NPC1POLBRAB9A | |
| SCHEMBL7662403 | 0.72 | KCNH2 (0.41) | CA1CA2CA7CA9 | |
| SCHEMBL7654006 | 0.72 | CA1 (0.30) | CA1CA2CA7CA9 | |
| SCHEMBL1865158 | 0.71 | CA1 (0.56) | POLBCA1CA2CA7CA9 | |
| SCHEMBL12545895 | 0.70 | HRH3 (0.42) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |