Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 10/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10785918 | 0.82 | KCNA3 (0.43) | KDM4EMAPK1TDP1RECQLMAPT | |
| SCHEMBL27448379 | 0.81 | KCNA3 (0.41) | RECQLL3MBTL1KCNA3 | |
| SCHEMBL7648797 | 0.80 | SMN1; SMN2 (0.51) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL2457210 | 0.80 | KDM4E (0.45) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL3167260 | 0.80 | KDM4E (0.49) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL17627814 | 0.80 | APP (0.53) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL7928494 | 0.80 | LMNA (0.41) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL7654202 | 0.80 | KDM4E (0.37) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL4981575 | 0.80 | APP (0.53) | KDM4EMAPK1TDP1APPRECQL | |
| SCHEMBL28556579 | 0.80 | KDM4E (0.49) | KDM4EMAPK1TDP1APPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002536440-A | — | — | 2002-10-29 | — | — | JP | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |