Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.47 |
| ▸ | ITGAV | P06756 | 13/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655338 | 0.94 | ITGB3 (0.49) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7651260 | 0.87 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7656164 | 0.86 | ITGB3 (0.48) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7656171 | 0.83 | ITGB3 (0.48) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7649886 | 0.81 | ITGB3 (0.59) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651363 | 0.80 | ITGB3 (0.51) | ITGB3ITGA2BITGAV | |
| SCHEMBL382408 | 0.78 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7052904 | 0.78 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7650189 | 0.76 | KDM4E (0.42) | — | |
| SCHEMBL7653647 | 0.75 | ITGB3 (0.61) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |