Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17254160 | 0.85 | LMNA (0.52) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL15222220 | 0.81 | ADRA2C (0.48) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL17084088 | 0.81 | ADRA2C (0.48) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL8094329 | 0.81 | AOC3 (0.43) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL17084114 | 0.81 | ADRA2C (0.48) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL17084095 | 0.81 | ADRA2C (0.48) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL11782455 | 0.76 | LMNA (0.48) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL28002029 | 0.74 | KDM4E (0.58) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL20336618 | 0.74 | LMNA (0.54) | LMNAADRA2CKDM4EADRA2AHIF1A | |
| SCHEMBL20336544 | 0.74 | LMNA (0.54) | LMNAADRA2CKDM4EADRA2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | disclosed |