Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29154642 | 0.78 | KDM4E (0.60) | KDM4ENPC1RAB9AHSD17B10CASP3 | |
| SCHEMBL3940682 | 0.76 | BACE1 (0.44) | ALDH1A1BACE1 | |
| SCHEMBL27780334 | 0.75 | NPC1 (0.59) | KDM4ENPC1RAB9AHSD17B10CASP3 | |
| SCHEMBL5470124 | 0.75 | BACE1 (0.46) | KDM4ERAB9AHSD17B10ALDH1A1HPGD | |
| SCHEMBL25591913 | 0.74 | ALDH1A1 (0.50) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL6673753 | 0.74 | BACE1 (0.49) | NPC1RAB9AALDH1A1BACE1SMN1; SMN2 | |
| SCHEMBL31094071 | 0.74 | BACE1 (0.49) | NPC1RAB9AALDH1A1BACE1SMN1; SMN2 | |
| SCHEMBL11743614 | 0.72 | NPC1 (0.72) | KDM4ENPC1RAB9AHSD17B10CASP3 | |
| SCHEMBL7721970 | 0.72 | HSD17B10 (0.69) | KDM4ENPC1RAB9AHSD17B10CASP3 | |
| SCHEMBL4039599 | 0.72 | BACE1 (0.43) | KDM4EHSD17B10ALDH1A1HPGDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492364-B1 | Triazolo and derivatives as chemokine inhibitors | TORAY INDUSTRIES, INC. (JP) | 2002-12-10 | — | — | US | disclosed |
| EP-1067130-A1 | TRIAZOLO DERIVATIVES AND CHEMOKINE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2001-01-10 | — | — | EP | disclosed |