Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.80 |
| ▸ | MMP9 | P14780 | 19/20 | 0.80 |
| ▸ | MMP13 | P45452 | 19/20 | 0.80 |
| ▸ | ADAM17 | P78536 | 18/20 | 0.80 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411705 | 0.91 | MMP1 (0.79) | MMP1MMP9MMP13ADAM17MMP2 | |
| Hydroxyamine SCHEMBL7651138 | 0.90 | MMP1 (0.81) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL7407646 | 0.90 | MMP1 (0.84) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL7411333 | 0.89 | MMP1 (1.00) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL6565358 | 0.79 | MMP1 (0.83) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL6568555 | 0.78 | MMP1 (0.76) | MMP1MMP9MMP13ADAM17CYP3A4 | |
| SCHEMBL7554869 | 0.77 | MMP9 (0.75) | MMP1MMP9MMP13ADAM17CYP3A4 | |
| SCHEMBL6566808 | 0.76 | CYP3A4 (0.80) | MMP1MMP9MMP13ADAM17CYP3A4 | |
| SCHEMBL7617789 | 0.76 | MMP1 (1.00) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL6567121 | 0.76 | MMP1 (0.80) | MMP1MMP9MMP13ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462073-B2 | METALLOPROTEASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION | 2002-10-08 | — | — | US | disclosed |