Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.68 |
| ▸ | ITGA2B | P08514 | 16/20 | 0.68 |
| ▸ | ITGAV | P06756 | 6/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415667 | 0.88 | ITGB3 (0.64) | ITGB3ITGA2BITGAV | |
| SCHEMBL382483 | 0.85 | ITGB3 (0.66) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651229 | 0.83 | TP53 (0.46) | ITGB3ITGA2BITGAVHTR2BTP53 | |
| SCHEMBL7402105 | 0.81 | ITGB3 (1.00) | ITGB3ITGA2BITGAV | |
| SCHEMBL383121 | 0.81 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7654405 | 0.81 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL7656759 | 0.81 | ITGB3 (0.56) | ITGB3ITGA2BITGAVHTR2B | |
| SCHEMBL382426 | 0.81 | ITGB3 (0.60) | ITGB3ITGA2BITGAVTP53 | |
| SCHEMBL7654273 | 0.80 | MAPT (0.44) | ITGB3ITGA2BHTR2BTP53MAPT | |
| SCHEMBL382318 | 0.80 | ITGB3 (0.59) | ITGB3ITGA2BITGAVMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |