Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.56 |
| ▸ | ITGAV | P06756 | 17/20 | 0.56 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.56 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655122 | 0.91 | ITGB3 (0.48) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL382281 | 0.86 | ITGB3 (0.62) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL7656748 | 0.85 | TP53 (0.45) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL7651260 | 0.82 | ITGB3 (0.55) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL7651216 | 0.81 | ITGB3 (0.68) | ITGB3ITGAVITGA2BHTR2B | |
| SCHEMBL7655119 | 0.80 | TP53 (0.41) | ITGB3ITGAVITGB5ITGA2BHTR2B | |
| SCHEMBL7656743 | 0.80 | FLT1 (0.44) | ITGB3ITGA2B | |
| SCHEMBL7652719 | 0.79 | ITGB3 (0.53) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL8506333 | 0.78 | ITGB3 (0.51) | ITGB3ITGAVITGB5ITGB1ITGA5 | |
| SCHEMBL8349376 | 0.78 | ITGB3 (0.51) | ITGB3ITGAVITGB5ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |