Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.48 |
| ▸ | ITGAV | P06756 | 14/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652719 | 0.85 | ITGB3 (0.53) | ITGB3ITGAVITGA2B | |
| SCHEMBL7651445 | 0.84 | JAK2 (0.38) | ITGB3ITGAVITGA2BJAK2JAK1 | |
| SCHEMBL7658383 | 0.83 | ITGB3 (0.49) | ITGB3ITGAVITGA2BJAK2JAK1 | |
| SCHEMBL7658303 | 0.80 | ITGB3 (0.49) | ITGB3ITGAVITGA2BJAK2JAK1 | |
| SCHEMBL7651194 | 0.79 | ITGB3 (0.74) | ITGB3ITGAVITGA2B | |
| SCHEMBL7655259 | 0.77 | ITGB3 (0.59) | ITGB3ITGAVITGA2BJAK2JAK1 | |
| SCHEMBL7658132 | 0.77 | ITGB3 (0.72) | ITGB3ITGAVITGA2B | |
| SCHEMBL7656164 | 0.76 | ITGB3 (0.48) | ITGB3ITGAVITGA2B | |
| SCHEMBL7656171 | 0.76 | ITGB3 (0.48) | ITGB3ITGAVITGA2B | |
| SCHEMBL7658501 | 0.75 | ITGB3 (0.57) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |