Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.49 |
| ▸ | ITGAV | P06756 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652072 | 0.86 | ITGB3 (0.42) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7652085 | 0.86 | ITGB3 (0.45) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7654471 | 0.85 | ITGB3 (0.52) | ITGB3ITGA2BITGAVMEN1ALDH1A1 | |
| SCHEMBL383017 | 0.83 | ITGB3 (0.70) | ITGB3ITGA2BITGAV | |
| SCHEMBL7658323 | 0.82 | JAK2 (0.41) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7658383 | 0.81 | ITGB3 (0.49) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7651194 | 0.81 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651433 | 0.80 | ITGB3 (0.48) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7651633 | 0.79 | NPC1 (0.55) | ITGB3ITGA2BMEN1ALDH1A1KMT2A | |
| SCHEMBL7655259 | 0.79 | ITGB3 (0.59) | ITGB3ITGA2BITGAVJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |