Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620186 | 0.92 | EGFR (0.43) | EGFRPTPN1PTPN2PTPN6NPC1 | |
| SCHEMBL964676 | 0.86 | NPC1 (0.46) | EGFRPTPN1PTPN2PTPN6NPC1 | |
| SCHEMBL7618868 | 0.85 | ACHE (0.42) | ACHEHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7615925 | 0.84 | PPARG (0.49) | ACHESMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL7528094 | 0.84 | NPC1 (0.46) | EGFRPTPN1PTPN2PTPN6NPC1 | |
| SCHEMBL7612401 | 0.84 | NPC1 (0.46) | EGFRPTPN1PTPN2PTPN6NPC1 | |
| SCHEMBL963777 | 0.82 | MEN1 (0.52) | PTPN1PTPN2PTPN6NPC1HPGD | |
| SCHEMBL7248873 | 0.81 | HCRTR2 (0.42) | ACHEEGFRPTPN1PTPN2PTPN6 | |
| SCHEMBL7245032 | 0.81 | BCHE (0.44) | ACHE | |
| SCHEMBL7243034 | 0.81 | HCRTR2 (0.42) | PTPN1PTPN2PTPN6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495701-B1 | THE PRESENT INVENTION IS DIRECTED TO PROCESSES FOR THE PREPARATION OF A COMPOUND USEFUL FOR TREATING DIABETES, OBESITY, HYPERLIPIDEMIA AND THE LIKE, | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2002-12-17 | — | — | US | disclosed |