Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612401 | 0.89 | NPC1 (0.46) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL964676 | 0.89 | NPC1 (0.46) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL963777 | 0.88 | MEN1 (0.52) | NPC1HPGDRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7651537 | 0.84 | ACHE (0.45) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL7620186 | 0.84 | EGFR (0.43) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL7529540 | 0.83 | MEN1 (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3292376 | 0.83 | CYP19A1 (0.48) | L3MBTL1PTPN1PTPN2PTPN6CYP19A1 | |
| SCHEMBL7531469 | 0.82 | MEN1 (0.43) | HPGDSMN1; SMN2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL27555431 | 0.80 | PTPN1 (0.43) | L3MBTL1PTPN1PTPN2PTPN6CYP19A1 | |
| SCHEMBL7532766 | 0.80 | L3MBTL1 (0.44) | L3MBTL1PTPN1PTPN2PTPN6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219604-A1 | METHOD FOR IMPROVING THE SOLUBILITY OF TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-1195371-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-04-10 | — | — | EP | disclosed |