Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10132049 | 0.81 | MAPT (0.52) | MAPTMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL2390130 | 0.80 | CYP4F2 (0.51) | MAPTMAPK1SMN1; SMN2LMNATRPM8 | |
| SCHEMBL6344652 | 0.80 | MAPT (0.54) | MAPTMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL9963987 | 0.80 | LMNA (0.41) | SMN1; SMN2LMNAKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL7651566 | 0.80 | SMN1; SMN2 (0.49) | MAPTMAPK1SMN1; SMN2LMNATRPM8 | |
| SCHEMBL2589045 | 0.79 | MAPT (0.61) | MAPTMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL30177224 | 0.79 | MAPT (0.61) | MAPTMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL7010780 | 0.79 | MAPT (0.53) | MAPTMAPK1SMN1; SMN2LMNATRPM8 | |
| SCHEMBL7052623 | 0.78 | PPIA (0.53) | MAPTMAPK1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL4061267 | 0.78 | MAPT (0.52) | MAPTMAPK1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1033366-A2 | Amide derivatives useful as Neuropeptide Y (NPY) antagonists | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |