Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.66 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656075 | 0.83 | ALOX5 (0.69) | ALOX5PIK3CDLMNAALDH1A1TSHR | |
| SCHEMBL8166180 | 0.80 | ALOX5 (0.67) | ALOX5PIK3CDLMNAALDH1A1TSHR | |
| SCHEMBL8173632 | 0.80 | ALOX5 (0.67) | ALOX5LMNAALDH1A1TSHRNPSR1 | |
| SCHEMBL332442 | 0.79 | ALOX5 (1.00) | ALOX5PIK3CDALDH1A1 | |
| SCHEMBL29405839 | 0.79 | ALOX5 (1.00) | ALOX5PIK3CDALDH1A1 | |
| SCHEMBL3568549 | 0.79 | ALOX5 (0.62) | ALOX5PIK3CDHRH3 | |
| Hydrochloric Acid SCHEMBL8173877 | 0.79 | ALOX5 (0.98) | ALOX5PIK3CDALDH1A1 | |
| SCHEMBL3563550 | 0.78 | ALOX5 (0.59) | ALOX5PIK3CDALDH1A1HRH3 | |
| SCHEMBL3569286 | 0.78 | ALOX5 (0.64) | ALOX5PIK3CDLMNAHRH3 | |
| Pf-4191834 SCHEMBL332973 | 0.78 | ALOX5 (0.81) | ALOX5PIK3CDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1291609-A | Method of preparing 5-lipoxidase inhibitor possessing different heterocyclic ring system | PFIZER PROD INC (US) | 2001-04-18 | — | — | CN | claimed |
| EP-1081146-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | claimed |
| US-6346624-B1 | ENZYME INHIBITORS FORMED BY DEHYDROHALOGENATION | PFIZER INC | 2002-02-12 | — | — | US | disclosed |
| US-6344563-B1 | SULFIDING, DEHYDROHALOGENATION, FORMATION OF BOND BETWEEN CARBON AND NITROGEN | NORRIS TIMOTHY (US) | 2002-02-05 | — | — | US | disclosed |
| US-6239285-B1 | REACTING A TETRAHYDRO-4-(3-(4-FLUOROPHENYL)THIO)PHENYL-2H-PYRAN-4-CARBOXA MIDE WITH HETEROCYCLE RING | PFIZER INC | 2001-05-29 | — | — | US | disclosed |
| CN-1291609-A | Method of preparing 5-lipoxidase inhibitor possessing different heterocyclic ring system | PFIZER PROD INC (US) | 2001-04-18 | — | — | CN | disclosed |
| EP-1081146-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081143-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081144-A2 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| CN-1286250-A | Method for preparing 5-lipooxygenase inhibitor having changeable heterocycle system | PFIZER PROD INC (US) | 2001-03-07 | — | — | CN | disclosed |