Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 5/20 | 0.42 |
| ▸ | F10 | P00742 | 5/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651526 | 0.85 | ITGB3 (0.45) | ITGB3ITGA2BALDH1A1PLAUITGAV | |
| SCHEMBL7654428 | 0.83 | ITGB3 (0.48) | ITGB3ITGA2BLMNAALDH1A1PKM | |
| SCHEMBL7658155 | 0.83 | MEN1 (0.51) | ITGB3ITGA2BUSP2LMNAALOX15 | |
| SCHEMBL7651971 | 0.81 | ITGB3 (0.72) | ITGB3ITGA2BITGAV | |
| SCHEMBL382764 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BMAPTITGAV | |
| SCHEMBL27551456 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BMAPTITGAV | |
| SCHEMBL7651229 | 0.79 | TP53 (0.46) | ITGB3ITGA2BMAPTITGAV | |
| SCHEMBL7651202 | 0.78 | ITGB3 (0.53) | ITGB3ITGA2BLMNAALDH1A1PKM | |
| SCHEMBL415668 | 0.76 | DRD4 (0.54) | ITGB3ITGA2BALDH1A1 | |
| SCHEMBL382937 | 0.76 | ITGB3 (0.66) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |