Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664593 | 0.84 | CCR5 (0.44) | MEN1KMT2ATGFBR1NAMPTITGB3 | |
| SCHEMBL7651979 | 0.83 | ITGB3 (0.47) | MAPTLMNAESRRGITGB3ITGA2B | |
| SCHEMBL26683376 | 0.83 | BCL2 (0.60) | MEN1KMT2ASMN1; SMN2CYP2C19HTT | |
| SCHEMBL7658148 | 0.82 | ITGB3 (0.68) | MEN1KMT2ASMN1; SMN2CYP2C19HTT | |
| SCHEMBL383059 | 0.81 | ITGB3 (0.43) | MEN1KMT2AMAPTLMNABCL2 | |
| SCHEMBL7654428 | 0.81 | ITGB3 (0.48) | SMN1; SMN2HTTMAPTLMNAITGB3 | |
| SCHEMBL7474671 | 0.78 | TGFBR1 (0.60) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL382554 | 0.77 | MMP13 (0.39) | SMN1; SMN2LMNAITGB3ITGA2BALDH1A1 | |
| SCHEMBL12720262 | 0.77 | KMT2A (0.64) | MEN1KMT2ASMN1; SMN2CYP2C19HTT | |
| SCHEMBL27551456 | 0.76 | ITGB3 (0.51) | MEN1KMT2AMAPTITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |