Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 12/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103658 | 0.83 | PNP (0.43) | PNPTRPV3 | |
| SCHEMBL7663658 | 0.80 | CXCR4 (0.35) | PNPTRPV3CXCR4PDCD1CD274 | |
| SCHEMBL7072329 | 0.76 | PNP (0.39) | PNPTRPV3 | |
| SCHEMBL7070778 | 0.76 | PNP (0.39) | PNPTRPV3 | |
| SCHEMBL7075461 | 0.76 | PNP (0.39) | PNPTRPV3 | |
| SCHEMBL7071084 | 0.76 | PNP (0.39) | PNPTRPV3 | |
| SCHEMBL7654878 | 0.75 | CXCR4 (0.41) | PNPCXCR4PDCD1CD274 | |
| SCHEMBL7108751 | 0.73 | PNP (0.39) | PNPTRPV3 | |
| SCHEMBL7659507 | 0.73 | TRPV3 (0.52) | PNPTRPV3 | |
| SCHEMBL7655174 | 0.73 | PNP (0.39) | PNPTRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |