Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.52 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151094 | 0.84 | CRHBP (0.56) | KCNA5KCNN4MAPTCRHBPCRHR2 | |
| SCHEMBL8650222 | 0.80 | ALDH1A1 (0.53) | KCNA5KCNN4MAPTTSHRS1PR1 | |
| SCHEMBL16484545 | 0.80 | TSHR (0.52) | KCNA5KCNN4MAPTTSHRADORA2A | |
| SCHEMBL5839123 | 0.80 | TSHR (0.52) | KCNA5KCNN4MAPTTSHRADORA2A | |
| SCHEMBL16408144 | 0.80 | NR3C2 (0.46) | MAPTCRHBPCRHR2NPSR1TSHR | |
| SCHEMBL14034729 | 0.79 | KCNN4 (0.48) | KCNA5KCNN4TSHRS1PR1CLK4 | |
| SCHEMBL27902396 | 0.79 | KCNN4 (0.48) | KCNA5KCNN4TSHRS1PR1CLK4 | |
| SCHEMBL27957290 | 0.77 | KCNN4 (0.47) | KCNA5KCNN4NPSR1TSHRS1PR1 | |
| SCHEMBL409370 | 0.77 | NR3C2 (0.57) | MAPTCRHBPCRHR2NPSR1TSHR | |
| SCHEMBL6567347 | 0.77 | NR3C2 (0.57) | MAPTCRHBPCRHR2NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002500641-A | — | — | 2002-01-08 | — | — | JP | claimed |
| CN-1259119-A | Substituted 3, 3-diamino-2-propenenitriles, their preparation and use | NOVO NORDISK AS (DK) | 2000-07-05 | — | — | CN | claimed |
| EP-0998451-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-10 | — | — | EP | claimed |
| WO-1998050344-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-12 | — | — | WO | claimed |
| CN-1259119-A | Substituted 3, 3-diamino-2-propenenitriles, their preparation and use | NOVO NORDISK AS (DK) | 2000-07-05 | — | — | CN | disclosed |
| EP-0998451-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-10 | — | — | EP | disclosed |
| US-5955548-A | POTASSIUM CHANNEL MODULATORS | NOVO NORDISK A/S (DK) | 1999-09-21 | — | — | US | disclosed |
| WO-1998050344-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-12 | — | — | WO | disclosed |