Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662659 | 0.92 | MAPT (0.50) | ABCG2MAPTLMNANPC1RAB9A | |
| SCHEMBL7654658 | 0.83 | APP (0.39) | ABCG2MAPTLMNANPC1RAB9A | |
| SCHEMBL7664550 | 0.81 | MAPT (0.43) | MAPTNPC1RAB9AATML3MBTL1 | |
| SCHEMBL7657631 | 0.81 | CYP1A1 (0.43) | ABCG2MAPTLMNANPC1RAB9A | |
| SCHEMBL7652008 | 0.81 | NR1H4 (0.47) | ABCG2MAPTNPC1RAB9AAPP | |
| SCHEMBL7664261 | 0.80 | AR (0.39) | ABCG2MAPTLMNANPC1RAB9A | |
| SCHEMBL7656619 | 0.79 | AURKA (0.48) | ABCG2MAPTATMMEN1KMT2A | |
| SCHEMBL7657806 | 0.78 | AR (0.51) | MAPTLMNARECQLL3MBTL1MEN1 | |
| SCHEMBL7666636 | 0.78 | AR (0.58) | MAPTLMNANPC1L3MBTL1MEN1 | |
| SCHEMBL7666145 | 0.78 | MAOB (0.58) | MAPTL3MBTL1CYP2C19MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |