SCHEMBL7664261

SCHEMBL7664261

Cc1cc(O)c(C(=O)C=CC2=COC(Cc3ccccc3)O2)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.39
ABCG2 Q9UNQ0 3/20 0.38
APP P05067 1/20 0.37
MAPT P10636 3/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GUSB P08236 1/20 0.36
MAOB P27338 3/20 0.35
MAOA P21397 1/20 0.35
NFE2L2 Q16236 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7654658 0.92 APP (0.39) ARABCG2APPMAPTKDM4E
SCHEMBL7664550 0.85 MAPT (0.43) ARMAPTALDH1A1MAPK1KMT2A
SCHEMBL7666636 0.85 AR (0.58) ARMAPTKDM4EMEN1ALDH1A1
SCHEMBL7654846 0.82 KDM4E (0.50) ARABCG2MAPTKDM4EMEN1
SCHEMBL7666145 0.81 MAOB (0.58) ARMAPTALDH1A1TDP1GUSB
SCHEMBL7657806 0.81 AR (0.51) ARMAPTKDM4EMEN1ALDH1A1
SCHEMBL7662659 0.80 MAPT (0.50) ABCG2APPMAPTKDM4EMEN1
SCHEMBL7652711 0.80 ABCG2 (0.60) ABCG2APPMAPTMEN1ALDH1A1
SCHEMBL7658891 0.78 NPC1 (0.40) ARMAPTMEN1ALDH1A1HPGD
SCHEMBL5138776 0.77 AR (0.63) ARABCG2MAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500846-B1 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE LG CHEMICAL, LTD. (KR) 2002-12-31 US disclosed
EP-1109800-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LIMITED (KR) 2001-06-27 EP disclosed
WO-2000012496-A1 NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE LG CHEMICAL LTD. (KR) 2000-03-09 WO disclosed