Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.53 |
| ▸ | TP53 | P04637 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TDP2 | O95551 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | APAF1 | O14727 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7650921 | 0.99 | MAPT (0.53) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6653595 | 0.81 | MAPT (0.48) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4958350 | 0.78 | MAPT (0.68) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6653588 | 0.78 | MAPT (0.49) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6648041 | 0.77 | MAPT (0.50) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6649263 | 0.77 | MAPT (0.47) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5573260 | 0.76 | ADORA1 (0.67) | ADORA1 | |
| Iodide SCHEMBL4960121 | 0.74 | ADORA1 (0.69) | ADORA1 | |
| SCHEMBL8666248 | 0.73 | MAPT (0.64) | MAPTTP53LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6191569 | 0.73 | ADORA1 (0.50) | MAPTTP53LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1161120-C | Use of polycyclic 2-aminothiazole systems for the preparation of medicaments for the prophylaxis or treatment of obesity | ���ĵ�˹ҩ��¹�����˾ | 2004-08-11 | — | — | CN | disclosed |
| US-6476059-B1 | Use of polycyclic 2-aminothiazole systems for the treatment of obesity | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-11-05 | — | — | US | disclosed |
| CN-1349404-A | Utilization of polycyclic 2-amino-thiazole systems in the production of medicaments for prophylaxis treatment of obesity | AVENTIS PHARMA GMBH (DE) | 2002-05-15 | — | — | CN | disclosed |