Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279530 | 0.88 | KDM4E (0.53) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL13852632 | 0.88 | HCAR2 (0.53) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL31533961 | 0.88 | PKM (0.67) | KDM4EPOLBALDH1A1HTTPKM | |
| SCHEMBL15228268 | 0.88 | PKM (0.67) | KDM4EPOLBALDH1A1HTTPKM | |
| SCHEMBL3321012 | 0.85 | NTRK2 (0.65) | KDM4EPOLBALDH1A1HPGDHTT | |
| SCHEMBL23015835 | 0.85 | SMYD3 (0.56) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL10671308 | 0.84 | POLB (0.47) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL13466415 | 0.84 | KDM4E (0.48) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL13741510 | 0.84 | PKM (0.48) | KDM4EPOLBGAAATMALDH1A1 | |
| SCHEMBL5909197 | 0.83 | THRB (0.61) | KDM4EPOLBGAAATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |