Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313449 | 0.86 | ALDH1A1 (0.56) | PARP1PARP2PRMT5WDR77HDAC6 | |
| SCHEMBL12922699 | 0.82 | HDAC6 (0.53) | PARP1PARP2PRMT5WDR77HDAC6 | |
| SCHEMBL3310243 | 0.79 | KDM4E (0.48) | PRMT5WDR77HDAC6F10ALDH1A1 | |
| SCHEMBL3309101 | 0.76 | ALDH1A1 (0.64) | PNMTPRMT5WDR77HDAC6ALDH1A1 | |
| SCHEMBL6421478 | 0.76 | NR1H2 (0.54) | PNMTHDAC6KDM4EMAPTNPC1 | |
| SCHEMBL25796678 | 0.74 | PARP1 (0.42) | PARP1PARP2PRMT5WDR77HDAC6 | |
| SCHEMBL29972349 | 0.74 | PNMT (0.44) | PNMTPRMT5WDR77HDAC6NPC1 | |
| SCHEMBL2761887 | 0.73 | ALDH1A1 (0.56) | PARP1PARP2PRMT5WDR77HDAC6 | |
| SCHEMBL10513283 | 0.73 | WDR91 (0.50) | PNMTPARP1PARP2PRMT5WDR77 | |
| SCHEMBL2461710 | 0.73 | ALDH1A1 (0.70) | PNMTALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405852-B1 | DIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2012-08-01 | — | — | EP | disclosed |
| EP-1270557-B1 | ETHYLENEDIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2431370-A1 | Monoacylated 1,2-diaminocycloalkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2012-03-21 | — | — | EP | disclosed |