Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650012 | 0.89 | MPO (0.44) | SMN1; SMN2POLBKDM4EL3MBTL1MAPT | |
| SCHEMBL7652031 | 0.89 | CA12 (0.44) | SMN1; SMN2POLBKDM4EL3MBTL1MAPT | |
| SCHEMBL7655615 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKDM4EL3MBTL1RAB9A | |
| SCHEMBL7648323 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBKDM4EL3MBTL1RAB9A | |
| SCHEMBL7650322 | 0.85 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBKDM4EL3MBTL1RAB9A | |
| SCHEMBL7649595 | 0.84 | KDM4E (0.47) | SMN1; SMN2KDM4ERAB9ANPC1MAPT | |
| SCHEMBL7649499 | 0.82 | CA9 (0.45) | SMN1; SMN2POLBKDM4EL3MBTL1RAB9A | |
| SCHEMBL10084842 | 0.80 | KDM4E (0.42) | POLBKDM4ENPC1MAPTKMT2A | |
| SCHEMBL8133826 | 0.78 | KDM4E (0.45) | SMN1; SMN2POLBKDM4ERAB9ANPC1 | |
| SCHEMBL7648338 | 0.77 | FEN1 (0.45) | SMN1; SMN2POLBKDM4EL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |