Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565838 | 0.87 | CYP2D6 (0.46) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL5291382 | 0.85 | SLC6A2 (0.55) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL14842376 | 0.85 | SLC6A2 (0.55) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL22190041 | 0.85 | SLC6A2 (0.55) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL5320862 | 0.84 | CYP2D6 (0.46) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL5283024 | 0.82 | SLC1A3 (0.50) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL5289685 | 0.81 | POLB (0.48) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL6533633 | 0.80 | CSNK1E (0.44) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL17476729 | 0.80 | RIPK1 (0.53) | CYP2D6MEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL497730 | 0.79 | CYP2C19 (0.72) | CYP2D6MEN1CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358978-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS (IN THE CASE OF INFLAMMATION), OSTEOARTHRITIS, ASTHMA, CARDIAC INFARCT, ALZHEIMER'S DISEASE, OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-19 | — | — | US | disclosed |