Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31221485 | 1.00 | OPRM1 (0.55) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL4064144 | 1.00 | OPRM1 (0.55) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL29980976 | 0.98 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL537135 | 0.98 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL29980665 | 0.94 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL536677 | 0.94 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL24455261 | 0.90 | OPRM1 (0.60) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL2265705 | 0.82 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL536557 | 0.81 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1GRIN1 | |
| SCHEMBL171507 | 0.81 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431357-A2 | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors | Incyte Corporation (US) | 2012-03-21 | — | — | EP | disclosed |