Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7184147 | 0.99 | MMP13 (0.45) | MMP13MMP2MMP14MMP12FPR2 | |
| SCHEMBL6394997 | 0.85 | MMP13 (0.45) | MMP13MMP2MMP14MMP12FPR2 | |
| SCHEMBL6098455 | 0.85 | MMP13 (0.49) | MMP13MMP2MMP14MMP12FPR2 | |
| Hydrochloric Acid SCHEMBL6688348 | 0.84 | MMP13 (0.45) | MMP13MMP2MMP14MMP12FPR2 | |
| SCHEMBL7394978 | 0.82 | MMP13 (0.48) | MMP13MMP2MMP14MMP12FPR2 | |
| SCHEMBL7653321 | 0.79 | MMP13 (0.47) | MMP13MMP2MMP14MMP12FPR2 | |
| Hydrochloric Acid SCHEMBL7184151 | 0.78 | MMP13 (0.47) | MMP13MMP2MMP14MMP12FPR2 | |
| SCHEMBL6096440 | 0.78 | MMP13 (0.49) | MMP13MMP2MMP14MMP12MMP1 | |
| SCHEMBL6095774 | 0.75 | MMP1 (0.54) | MMP13MMP2MMP14MMP1MMP3 | |
| SCHEMBL6097329 | 0.75 | MMP13 (0.49) | MMP13MMP2MMP14MMP12MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448250-B1 | INHIBITS THE ACTIVITY OF ONE OR MORE OF THE FOLLOWING MATRIX METALLOPROTEINASES: MMP-2, MMP-9, AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITORY ACTIVITY AGAINST MMP-1 | G. D. SEARLE & COMPANY | 2002-09-10 | — | — | US | disclosed |