Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.68 |
| ▸ | LTA4H | P09960 | 3/20 | 0.62 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.56 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653222 | 1.00 | HRH3 (0.68) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| SCHEMBL7675738 | 0.99 | HRH3 (0.68) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| SCHEMBL7653972 | 0.92 | HRH3 (0.70) | HRH3KCNH2HRH1 | |
| SCHEMBL7682850 | 0.86 | CA12 (0.70) | HRH3KCNH2LTA4HHRH1CHRM1 | |
| Hydrochloric Acid SCHEMBL7653228 | 0.86 | HRH3 (0.68) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| Hydrochloric Acid SCHEMBL7653369 | 0.86 | HRH3 (0.68) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| SCHEMBL7656308 | 0.86 | HRH3 (0.69) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| Hydrochloric Acid SCHEMBL7675743 | 0.84 | HRH3 (0.68) | HRH3KCNH2LTA4HPSMB1PSMB5 | |
| SCHEMBL7007208 | 0.82 | CA12 (0.75) | HRH3KCNH2LTA4HCYP2D6CHRM1 | |
| SCHEMBL7654898 | 0.81 | LTA4H (0.49) | HRH3KCNH2LTA4HHRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |