Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.43 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445488 | 0.84 | GPR119 (0.53) | GPR119EPHX1STS | |
| SCHEMBL22441470 | 0.84 | GPR119 (0.53) | GPR119EPHX1STS | |
| SCHEMBL6402117 | 0.82 | TGFBR1 (0.53) | GPR119MAPT | |
| SCHEMBL25819368 | 0.80 | GPR119 (0.56) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL25819386 | 0.80 | GPR119 (0.56) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL13600068 | 0.80 | GPR119 (0.56) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL25033887 | 0.78 | GPR119 (0.55) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL119948 | 0.78 | GPR119 (0.55) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL7495690 | 0.78 | GPR119 (0.55) | GPR119EPHX1NPC1ALDH1A1MAPT | |
| SCHEMBL22445587 | 0.77 | GPR119 (0.54) | GPR119EPHX1NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355655-B1 | TREATING A COGNITIVE DISORDER, A NEURO-DEGENERATIVE DISORDER; AGE-RELATED DEMENTIA; AGE-INDUCED MEMORY IMPAIRMENT; A MOVEMENT DISORDER, ATTENTION DEFICIT DISORDER; ATTENTION DEFICIT HYPERACTIVITY DISORDER; PSYCHOSIS; COGNITIVE DEFICITS | ELI LILLY AND COMPANY | 2002-03-12 | — | — | US | disclosed |
| EP-1100498-A4 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1100498-A1 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | Eli Lilly & Company (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006159-A1 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |