Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546031 | 0.86 | NPC1 (0.60) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL6356948 | 0.86 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL6363447 | 0.75 | KMT2A (0.43) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL27979643 | 0.68 | MEN1 (0.84) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL7007596 | 0.66 | RORC (0.46) | NPC1RAB9ATMPRSS2 | |
| Hydrochloric Acid SCHEMBL7847628 | 0.65 | RORC (0.45) | NPC1RAB9ATMPRSS2 | |
| SCHEMBL10253264 | 0.65 | KMT2A (0.69) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL10340230 | 0.65 | SIGMAR1 (0.62) | CYP3A4CYP2D6CYP2C19HPGDTSHR | |
| SCHEMBL9698861 | 0.65 | SIGMAR1 (0.66) | CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL9698870 | 0.65 | SIGMAR1 (0.66) | CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429317-B1 | MUSCARINIC RECEPTOR MODULATORS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; SCHIZOPHRENIA | ELI LILLY AND COMPANY | 2002-08-06 | — | — | US | disclosed |
| US-6395735-B2 | AN INDANE-LIKE COMPOUNDS WHICH CAN BE USEFUL FOR TREATING PSYCHOSIS AND OTHER CONDITIONS ASSOCIATED WITH MODULATION OF A MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY | 2002-05-28 | — | — | US | disclosed |
| US-20010012848-A1 | Pharmaceutical compounds | HOLLINSHEAD SEAN PATRICK (US) | 2001-08-09 | — | — | US | disclosed |
| US-6211364-B1 | PSYCHOLOGICAL DISORDERS; ALZHEIMER'S DISEASE; CROHN'S DISEASE; PARKINSON DISEASES | ELI LILLY AND COMPANY | 2001-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012848-A1 | Pharmaceutical compounds | CHRM5, CHRM4, CHRM3 | MEN1 1772/4885KMT2A 1606/4885NPC1 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.