Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652021 | 0.90 | ITGB3 (0.41) | ITGB3ITGA2BITGAVCASRNPC1 | |
| SCHEMBL7654428 | 0.87 | ITGB3 (0.48) | SLC6A7ITGB3ITGA2BITGAVNPC1 | |
| SCHEMBL7651967 | 0.85 | ITGB3 (0.49) | HSD11B1ITGB3ITGA2BITGAVCASR | |
| SCHEMBL7653647 | 0.83 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7649898 | 0.83 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651415 | 0.83 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7464453 | 0.79 | ITGB3 (0.54) | ITGB3ITGA2BITGAVCASRLMNA | |
| SCHEMBL27551456 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BITGAVCASR | |
| SCHEMBL382764 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BITGAVCASR | |
| SCHEMBL7658101 | 0.78 | ITGB3 (0.48) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |