Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170220 | 0.89 | MAPT (0.55) | PPARGACSS2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7649076 | 0.83 | PPARG (0.54) | PPARGSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6495333 | 0.81 | ALDH1A1 (0.44) | PPARGACSS2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6497514 | 0.80 | ALDH1A1 (0.46) | PPARGACSS2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6503682 | 0.80 | ALDH1A1 (0.43) | ACSS2SMN1; SMN2ALDH1A1MAPTBRD4 | |
| SCHEMBL7654112 | 0.78 | PPARG (0.55) | PPARGSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6169794 | 0.77 | PTGES (0.57) | PPARGACSS2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6170044 | 0.76 | PPARG (0.64) | PPARGACSS2SMN1; SMN2LMNANPC1 | |
| SCHEMBL7656289 | 0.76 | PPARG (0.69) | PPARGALDH1A1MAPTLMNANPC1 | |
| SCHEMBL5673971 | 0.76 | PTGDR2 (0.40) | ACSS2SMN1; SMN2ALDH1A1MAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1020452-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |