Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 5/20 | 0.49 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7664647 | 0.99 | HRH1 (0.55) | HRH1HRH3SIGMAR1HTR1AHTR2A | |
| SCHEMBL7681283 | 0.89 | HRH1 (0.57) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL7675906 | 0.86 | HRH1 (0.54) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL7652320 | 0.86 | HRH1 (0.54) | HRH1HRH3SIGMAR1OPRM1OPRK1 | |
| SCHEMBL7660411 | 0.84 | HRH1 (0.53) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL7675873 | 0.81 | HRH1 (0.49) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL11718665 | 0.81 | HRH1 (0.65) | HRH1HRH3SIGMAR1 | |
| SCHEMBL7657109 | 0.81 | ADRA1A (0.71) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL7675326 | 0.79 | HRH1 (0.47) | HRH1HRH3SIGMAR1ADRA1AADRA1D | |
| SCHEMBL7657286 | 0.79 | HRH1 (0.51) | HRH1HRH3SIGMAR1ADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436962-B1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS; RELIEF FROM BENIGN PROSTATIC HYPERPLASIA BY LESS HINDERED URINE FLOW BY RELAXING SMOOTH MUSCLE TISSUE; WITH A TESTOSTERONE 5-ALPHA REDUCTASE INHIBITOR, FINASTERIDE; ACUTE AND CHRONIC RELIEF | MERCK & CO., INC. | 2002-08-20 | — | — | US | disclosed |