Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273112 | 0.85 | LMNA (0.45) | TDP1ALDH1A1THRBMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL273187 | 0.84 | LMNA (0.44) | TDP1ALDH1A1THRBMAPTKDM4E | |
| SCHEMBL27919377 | 0.83 | TDP1 (0.44) | TDP1ALDH1A1THRBMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5710125 | 0.82 | TDP1 (0.43) | TDP1ALDH1A1THRBMAPTKDM4E | |
| SCHEMBL2476369 | 0.82 | TDP1 (0.38) | TDP1ALDH1A1THRBMAPTMEN1 | |
| SCHEMBL7162754 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL2476365 | 0.79 | TDP1 (0.40) | TDP1ALDH1A1THRBMAPTKDM4E | |
| SCHEMBL2720971 | 0.79 | TDP1 (0.47) | TDP1ALDH1A1MAPTKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL4432331 | 0.78 | MAPT (0.49) | TDP1ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL278949 | 0.72 | TDP1 (0.51) | TDP1ALDH1A1THRBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994114-B1 | Process for the preparation of imidazoquinazolinone derivatives | SHIRE US INC (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-0994114-A2 | Process for the preparation of imidazoquinazolinone derivatives | ROBERTS LABORATORIES INC. (US) | 2000-04-19 | — | — | EP | disclosed |
| US-5801245-A | Process for the preparation of ethyl-N-(2,3 dichloro-6-nitrobenzyl) glycine | ROBERTS LABORATORIES INC. (US) | 1998-09-01 | — | — | US | disclosed |
| EP-0778258-A2 | Process for the preparation of ethyl-n-(2,3 dichloro-6-nitrobenzyl) glycine | ROBERTS LABORATORIES INC. (US) | 1997-06-11 | — | — | EP | disclosed |