SCHEMBL765410

SCHEMBL765410

C[C@@H]1C[C@@H]1N(C)C(=O)c1occc1Cc1ccc(F)cc1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC5A1 P13866 1/20 0.34
SLC5A2 P31639 1/20 0.34
CNR1 P21554 3/20 0.34
CNR2 P34972 3/20 0.34
MAPT P10636 1/20 0.33
PDK2 Q15119 2/20 0.33
NSD2 O96028 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
HSP90AA1 P07900 1/20 0.32
OPRM1 P35372 2/20 0.32
AGER Q15109 2/20 0.32
KCNH2 Q12809 1/20 0.32
MTNR1A P48039 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12206799 0.78 PTGER4 (0.36) CNR1CNR2MAPTNSD2MEN1
SCHEMBL765412 0.75 KMT2A (0.39) CNR2KMT2AHSP90AA1
SCHEMBL754893 0.73 KMT2A (0.50) KMT2AHSP90AA1TDP1CYP2C19
SCHEMBL27861736 0.72 MAPT (0.39) CNR2MAPTMEN1KMT2AHSP90AA1
Tert-Butyl Formate SCHEMBL27588377 0.68 MAOB (0.34) CNR2MAPTMEN1KMT2AHSP90AA1
SCHEMBL4675592 0.66 ALDH1A1 (0.36) MEN1KMT2AHSP90AA1
SCHEMBL4675595 0.66 ALDH1A1 (0.36) MEN1KMT2AHSP90AA1
SCHEMBL2489939 0.65 LIPG (0.49) HSP90AA1
SCHEMBL16921549 0.64 CA12 (0.38) CNR1CNR2MAPTKMT2AHSP90AA1
SCHEMBL753000 0.64 CA12 (0.38) CNR1CNR2MAPTKMT2AHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1422218-B1 ANTIVIRAL AGENT SHIONOGI & CO (JP) 2012-03-21 EP disclosed