Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655905 | 0.95 | EGLN1 (0.39) | EGLN1TRPM8IGF1RFGFR1FGFR2 | |
| Acetic Acid SCHEMBL7654019 | 0.89 | EGLN1 (0.40) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| SCHEMBL7657220 | 0.88 | CAMK2D (0.42) | CAMK2D | |
| SCHEMBL7661373 | 0.87 | TRPM8 (0.34) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| Acetic Acid SCHEMBL7654130 | 0.85 | EGLN1 (0.38) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| SCHEMBL7837818 | 0.85 | EGLN1 (0.36) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| Acetic Acid SCHEMBL7837822 | 0.85 | CHEK1 (0.38) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| Acetic Acid SCHEMBL7817717 | 0.85 | EGLN1 (0.40) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| Acetic Acid SCHEMBL7817718 | 0.85 | CAMK2D (0.39) | EGLN1TRPM8IGF1RCNR1CNR2 | |
| Acetic Acid SCHEMBL8368547 | 0.85 | EGLN1 (0.48) | EGLN1IGF1RCAMK2DCHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |