SCHEMBL7654277

SCHEMBL7654277

COc1ccc(Cn2c(=O)c3cc(Cl)ccc3n(CCCCBr)c2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 1/20 0.45
HDAC1 Q13547 3/20 0.45
HDAC6 Q9UBN7 2/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
MAPT P10636 4/20 0.44
THRB P10828 1/20 0.44
P2RX4 Q99571 1/20 0.44
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 2/20 0.43
KMT2A Q03164 2/20 0.43
POLB P06746 1/20 0.43
ALOX12 P18054 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
PARG Q86W56 1/20 0.43
RXFP1 Q9HBX9 1/20 0.42
PTGS1 P23219 1/20 0.42
PTGS2 P35354 1/20 0.42
RGS12 O14924 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7648333 0.92 HDAC6 (0.48) CCR2HDAC1HDAC6HDAC11HDAC8
SCHEMBL7648500 0.89 HDAC1 (0.45) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7648551 0.86 HDAC1 (0.51) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7648583 0.86 HDAC1 (0.59) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7651811 0.85 TDP1 (0.47) KMT2A
SCHEMBL7654886 0.85 HDAC1 (0.48) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7656537 0.82 HDAC1 (0.47) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7650053 0.80 HDAC1 (0.52) HDAC1HDAC6HDAC11HDAC8MAPT
SCHEMBL7652126 0.79 TDP1 (0.47) HDAC1HDAC6HDAC8KMT2ATP53
SCHEMBL7655267 0.77 MAPT (0.69) HDAC1HDAC6HDAC11HDAC8MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407116-B1 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS TAKEDA CHEMICAL INDUSTRIES, INC. (JP) 2002-06-18 US disclosed
EP-1026160-A1 NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS Takeda Chemical Industries, Ltd. (JP) 2000-08-09 EP disclosed