Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648551 | 0.87 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7654277 | 0.85 | CCR2 (0.45) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7648500 | 0.85 | HDAC1 (0.45) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7656537 | 0.83 | HDAC1 (0.47) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7650053 | 0.82 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7648583 | 0.81 | HDAC1 (0.59) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7651811 | 0.81 | TDP1 (0.47) | — | |
| SCHEMBL7648333 | 0.79 | HDAC6 (0.48) | HDAC1HDAC8HDAC6HDAC11MAPT | |
| SCHEMBL7649548 | 0.76 | HDAC1 (0.46) | HDAC1HDAC8HDAC6MAPTGAA | |
| SCHEMBL7654891 | 0.76 | PTGS2 (0.41) | HDAC1HDAC8HDAC6HDAC11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |