⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554446 | 0.78 | — | — | |
| SCHEMBL16089 | 0.78 | — | — | |
| SCHEMBL17214811 | 0.77 | — | — | |
| SCHEMBL9515654 | 0.69 | — | — | |
| SCHEMBL2742995 | 0.69 | — | — | |
| SCHEMBL1669222 | 0.69 | — | — | |
| Acetone SCHEMBL497759 | 0.67 | LMNA (0.32) | — | |
| Itaconic Anhydride SCHEMBL25233 | 0.65 | — | — | |
| SCHEMBL7654370 | 0.65 | — | — | |
| SCHEMBL18831086 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1346830-A | Novel 2,4-dioxopyrrolidone and 2,4-dioxotetrahydro-furan derivs. and medicine contg. them as active component | LEAD CHEM CO LTD (JP) | 2002-05-01 | — | — | CN | disclosed |
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| EP-0936221-A4 | NOVEL 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRAHYDROFURAN DERIVATIVES AND MEDICINES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | LEAD CHEM CO LTD (JP) | 2001-12-19 | — | — | EP | disclosed |
| CN-1074412-C | Novel 2, 4-dioxopyrrolidine and 2, 4-dioxotetrahydrofuran derivatives and drugs containing the same as active ingredient | LEAD CHEM CO LTD (JP) | 2001-11-07 | — | — | CN | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |
| CN-1234032-A | Novel 2, 4-dioxopyrrolidine and 2, 4-dioxotetrahydrofuran derivatives and drugs containing the same as active ingredient | LEAD CHEM CO LTD (JP) | 1999-11-03 | — | — | CN | disclosed |
| EP-0936221-A1 | NOVEL 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRAHYDROFURAN DERIVATIVES AND MEDICINES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | LEAD CHEMICAL COMPANY LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |
| EP-0936221-A1 | NOVEL 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRAHYDROFURAN DERIVATIVES AND MEDICINES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | LEAD CHEMICAL COMPANY LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |
| WO-1998012194-A1 | NOVEL 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRAHYDROFURAN DERIVATIVES AND MEDICINES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | LEAD CHEMICAL CO., LTD. (JP) | 1998-03-26 | — | — | WO | disclosed |