Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693307 | 0.79 | CYP19A1 (0.61) | CYP19A1HDAC1HDAC6SMN1; SMN2HTT | |
| SCHEMBL7674570 | 0.78 | CYP19A1 (0.79) | CYP19A1HDAC1HDAC6SMN1; SMN2LMNA | |
| SCHEMBL950133 | 0.78 | CYP19A1 (0.62) | CYP19A1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL7657762 | 0.78 | CYP19A1 (0.43) | CYP19A1HDAC1HDAC6STS | |
| SCHEMBL15688800 | 0.77 | CYP19A1 (0.71) | CYP19A1HDAC1HDAC6STS | |
| SCHEMBL16494597 | 0.77 | CYP19A1 (0.53) | CYP19A1HDAC1HDAC6MAPT | |
| SCHEMBL6700110 | 0.76 | CYP19A1 (0.56) | CYP19A1HDAC1HDAC6SMN1; SMN2HTT | |
| SCHEMBL7655658 | 0.76 | CYP19A1 (0.75) | CYP19A1STS | |
| SCHEMBL17159812 | 0.75 | CYP19A1 (0.80) | CYP19A1HDAC1HDAC6 | |
| SCHEMBL7653403 | 0.74 | CYP19A1 (0.37) | CYP19A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |