Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 16/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010306 | 0.86 | BDKRB2 (0.55) | BDKRB2 | |
| SCHEMBL7009616 | 0.86 | BDKRB2 (0.44) | BDKRB2 | |
| SCHEMBL7009652 | 0.84 | BDKRB2 (0.47) | BDKRB2 | |
| SCHEMBL7654574 | 0.80 | BDKRB2 (0.53) | BDKRB2 | |
| SCHEMBL7654575 | 0.80 | BDKRB2 (0.53) | BDKRB2 | |
| SCHEMBL7667265 | 0.79 | BDKRB2 (0.54) | BDKRB2SMN1; SMN2KDM4EPOLB | |
| SCHEMBL7667268 | 0.79 | BDKRB2 (0.54) | BDKRB2SMN1; SMN2KDM4EPOLB | |
| SCHEMBL7005682 | 0.77 | KDM4E (0.33) | BDKRB2KDM4EALDH1A1 | |
| SCHEMBL7007288 | 0.73 | BDKRB2 (0.78) | BDKRB2 | |
| SCHEMBL7007285 | 0.73 | BDKRB2 (0.78) | BDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344462-B1 | Heterocyclic compounds as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-05 | — | — | US | disclosed |
| US-6100284-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-08 | — | — | US | disclosed |
| US-6008229-A | TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0861243-A1 | HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997011069-A1 | HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-27 | — | — | WO | disclosed |