Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651816 | 0.98 | SPHK1 (0.47) | SPHK1SPHK2FFAR4SIGMAR1MEN1 | |
| SCHEMBL7650285 | 0.98 | SPHK1 (0.51) | SPHK1SPHK2FFAR4SIGMAR1MEN1 | |
| SCHEMBL7647363 | 0.96 | SPHK1 (0.50) | SPHK1SPHK2FFAR4SIGMAR1 | |
| SCHEMBL7652663 | 0.94 | SPHK1 (0.46) | SPHK1SPHK2FFAR4SIGMAR1MEN1 | |
| SCHEMBL7650177 | 0.93 | SPHK1 (0.45) | SPHK1SPHK2FFAR4SIGMAR1 | |
| SCHEMBL3146239 | 0.86 | SPHK1 (0.41) | SPHK1FFAR4CYP3A4CYP2D6 | |
| SCHEMBL5544467 | 0.85 | SPHK1 (0.40) | SPHK1KMT2A | |
| SCHEMBL11336354 | 0.81 | SPHK1 (0.71) | SPHK1SPHK2TP53CYP3A4 | |
| SCHEMBL5678879 | 0.80 | SPHK1 (0.69) | SPHK1SPHK2TP53CYP3A4 | |
| SCHEMBL7650842 | 0.80 | DRD2 (0.45) | SIGMAR1MEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492364-B1 | Triazolo and derivatives as chemokine inhibitors | TORAY INDUSTRIES, INC. (JP) | 2002-12-10 | — | — | US | disclosed |
| EP-1067130-A1 | TRIAZOLO DERIVATIVES AND CHEMOKINE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2001-01-10 | — | — | EP | disclosed |