Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666636 | 0.87 | AR (0.58) | KDM4EMAPTARMAOBMEN1 | |
| SCHEMBL7664261 | 0.82 | AR (0.39) | KDM4EMAPTARMAOBMEN1 | |
| SCHEMBL7664988 | 0.81 | AR (0.52) | KDM4EMAPTARAKR1C4AKR1C3 | |
| SCHEMBL7661260 | 0.81 | MAOB (0.41) | KDM4EMAPTARMAOBCYSLTR1 | |
| SCHEMBL7654658 | 0.80 | APP (0.39) | KDM4EMAPTARMAOBMEN1 | |
| SCHEMBL7664550 | 0.80 | MAPT (0.43) | MAPTARMAOBHTTKMT2A | |
| SCHEMBL7657806 | 0.79 | AR (0.51) | KDM4EMAPTARMAOBMEN1 | |
| SCHEMBL7666145 | 0.79 | MAOB (0.58) | MAPTARMAOBNPSR1TDP1 | |
| SCHEMBL5220133 | 0.78 | HCAR2 (0.43) | KDM4EMAPTNFKB1NPC1RAB9A | |
| SCHEMBL7652008 | 0.77 | NR1H4 (0.47) | MAPTARMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |