Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 6/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14665877 | 0.83 | HSD17B10 (0.44) | PDCD1CD274HSD17B10NPSR1POLB | |
| SCHEMBL5255891 | 0.81 | PDCD1 (0.44) | PDCD1CD274HSD17B10KDM4ELTA4H | |
| SCHEMBL14658982 | 0.81 | HSD17B10 (0.43) | PDCD1CD274HSD17B10KDM4EPOLB | |
| SCHEMBL7107855 | 0.81 | HSD17B10 (0.47) | PDCD1CD274HSD17B10KDM4EPOLB | |
| SCHEMBL7652140 | 0.80 | PNP (0.39) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL7650291 | 0.79 | POLB (0.42) | PDCD1CD274HSD17B10KDM4ETSHR | |
| SCHEMBL7658936 | 0.78 | KMT2A (0.45) | POLBKMT2AMAPTS1PR1MEN1 | |
| SCHEMBL7650963 | 0.76 | KMT2A (0.39) | KDM4EPOLBKMT2AMAPTMEN1 | |
| SCHEMBL14659260 | 0.76 | CYP2C19 (0.43) | PDCD1CD274HSD17B10KDM4ETSHR | |
| SCHEMBL17195529 | 0.74 | CARM1 (0.41) | PDCD1CD274HSD17B10KDM4ES1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |