Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652140 | 0.88 | PNP (0.39) | KMT2AMEN1LMNAAGERMAPT | |
| SCHEMBL7650963 | 0.87 | KMT2A (0.39) | KMT2AMEN1LMNAAGERMAPT | |
| SCHEMBL7108600 | 0.84 | TYMP (0.41) | KMT2AMEN1LMNAS1PR1AGER | |
| SCHEMBL7660448 | 0.81 | PNP (0.37) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL7655038 | 0.78 | PDCD1 (0.44) | KMT2AMEN1LMNAS1PR1MAPT | |
| SCHEMBL12892465 | 0.76 | POLB (0.44) | KMT2AMEN1S1PR1AGERALDH1A1 | |
| SCHEMBL7655922 | 0.74 | TYMP (0.39) | KMT2AMEN1S1PR1AGERPOLB | |
| SCHEMBL7108601 | 0.74 | TYMP (0.39) | KMT2AMEN1S1PR1AGERALDH1A1 | |
| SCHEMBL7656330 | 0.74 | ALDH1A1 (0.40) | KMT2AMEN1LMNAS1PR1AGER | |
| SCHEMBL17823521 | 0.74 | DNM1 (0.59) | KMT2AMEN1LMNAAGERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |