Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | AGER | Q15109 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658936 | 0.88 | KMT2A (0.45) | KMT2ALMNAMEN1MAPTCNR2 | |
| SCHEMBL7650963 | 0.86 | KMT2A (0.39) | KMT2ALMNAMEN1MAPTCHRNB2 | |
| SCHEMBL7103584 | 0.83 | PNP (0.44) | PNP | |
| SCHEMBL7659401 | 0.82 | MAPT (0.30) | MAPT | |
| SCHEMBL7655038 | 0.80 | PDCD1 (0.44) | KMT2ALMNAMEN1MAPTCHRNB2 | |
| SCHEMBL7653615 | 0.75 | PDCD1 (0.40) | PNPKMT2ALMNAMEN1MAPT | |
| SCHEMBL7106657 | 0.75 | PNP (0.39) | PNP | |
| SCHEMBL7660955 | 0.75 | PNP (0.39) | PNPCNR2 | |
| SCHEMBL7659642 | 0.75 | PNP (0.39) | PNPKMT2AMEN1CHRNB2CHRNA4 | |
| SCHEMBL14873858 | 0.71 | KMT2A (0.53) | KMT2ALMNAMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |