Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 5/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655057 | 1.00 | SNCA (0.58) | SNCAMAOBBCHECYP1B1PTGS2 | |
| SCHEMBL7717263 | 0.90 | SNCA (0.53) | SNCAMAOBBCHECYP1B1PTGS2 | |
| SCHEMBL7717261 | 0.90 | SNCA (0.53) | SNCAMAOBBCHECYP1B1PTGS2 | |
| SCHEMBL7649969 | 0.87 | SNCA (0.60) | SNCAMAOBHSP90AA1LMNAALDH1A1 | |
| SCHEMBL7649962 | 0.87 | SNCA (0.60) | SNCAMAOBHSP90AA1LMNAALDH1A1 | |
| SCHEMBL7655923 | 0.85 | LMNA (0.55) | SNCAMAOBBCHECYP1B1LMNA | |
| SCHEMBL7655913 | 0.85 | LMNA (0.55) | SNCAMAOBBCHECYP1B1LMNA | |
| SCHEMBL10496508 | 0.83 | SNCA (0.60) | SNCAMAOBBCHECYP1B1PTGS2 | |
| SCHEMBL9797743 | 0.83 | SNCA (0.60) | SNCAMAOBBCHECYP1B1PTGS2 | |
| SCHEMBL27499697 | 0.79 | CES1 (0.70) | MAOBBCHECYP1B1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6491903-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY | WASHINGTON UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-6383500-B1 | Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications | WASHINGTON UNIVERSITY | 2002-05-07 | — | — | US | disclosed |